Craig Granowitz
Chief Medical Officer Lexicon Pharmaceuticals
Craig B. Granowitz, M.D., Ph.D. has been our Senior Vice President and Chief Medical Officer since August 2021. Dr. Granowitz previously served as Chief Medical Officer of Amarin Corporation plc since 2016. Prior to joining Amarin, Dr. Granowitz served as Senior Vice President and Head of Global Medical Affairs, Global Human Health of Merck & Co., Inc. and in a variety of medical and commercial management positions for Schering-Plough Corporation. Dr. Granowitz received his B.A. from Dartmouth College and his M.D. and Ph.D. from Columbia University.
Seminars
Thursday 29th January 2026
Pilavapadin: A Novel Non-Opioid Mechanism of Action for Neuropathic Pain – Translational Insights from Preclinical to Clinical Studies
10:00 am
- Pilavapadin, a first-in-class AAK1 inhibitor, offers a differentiated non-opioid mechanism for treating neuropathic pain, addressing limitations of current therapies
- Robust efficacy in multiple preclinical pain models supported advancement into clinical studies, which demonstrated target engagement, favourable PK, and a tolerable safety profile
- Clinical trials in neuropathic pain revealed analgesic activity and provided critical insights on dose optimization, patient variability, and trial design challenges in neuropathic pain
